Endocrine Abstracts

Introduction: In thyrotoxicosis, the clinical syndrome of excess circulating thyroid hormones, differentiation must be made between thyrotoxicosis with increased or decreased radio-iodine tracer uptake on thyroid scintigraphy. A cause of thyrotoxicosis with decreased radio-iodine uptake is iodine excess. In patients not taking any medication and without any history of recent radiological imaging studies, the confirmation of iodine excess as the cause of the thyrotoxicosis is d...

Background: Primary thyroid lymphoma (PTL) is a rare thyroid tumor that accounts for only 5% of thyroid malignancies, but is associated with higher mortality than differentiated thyroid cancer. The major risk factor for thyroid lymphoma is the presence of Hashimoto’s thyroiditis (HT) with an estimated 60-fold increased risk. The lymphocytic infiltrate in HT appears to develop into lymphoma in a minority of patients. The differential diagnosis between Hashimoto’s thyr...

Objective: To identify MetS and non-MetS in subjects with adult-onset GHD before start of GH replacement and to compare prevalence of cardiovascular risk factors.Subjects and methods: MetS was defined (IDF criteria) by the obligatory presence of increased waist circumference (WC) and presence of at least two of following components: hypertension, decreased HDL-cholesterol, increased triglycerides, diabetes mellitus. The complementary group was defined as...

Background: Untreated GH-deficiency (GHD) in adults has been suggested to be associated with an increased prevalence of type 2 diabetes mellitus (DM). Proposed causative factors are the tendency to overweight and the insulin resistance due to central adiposity.Patients and methods: The KIMS (Pfizer International Metabolic Database) was used to evaluate the prevalence of DM in both childhood-onset (CO; n=1977; 56% males) and in adult-onset (AO; ...